In 2008 Paz Gutierrez founded BIOMS, a new interdisciplinary research initiative intersecting architecture and sciences. BIOMS seeks to promote and define next-generation material organizations for the built environment in synergy with the ever evolving dynamics of ecosystems. By interrelating design and bio-physics through a new cross-disciplinary practice between architecture and bio-engineering, BIOMS is developing pioneering material systems through biologically inspired technologies. BIOMS’ research agenda studies new precision and integrated methods to redirect, concentrate, and exchange energy, as well as, to redistribute and metabolize matter, contributing to the development of autotrophic built environments. Advanced computational and material analysis of environmental flows is being developed to study methods of bio-synthetic compatibilization integrated into building systems and infrastructures. With the aim to produce effective energy and material balances, we are venturing into new methods of synchronizing synthetic and LIVE matter as active building agents.